Gastrointestinal diseases of the digestive system
Conditions
Interventions
FMT Treatment Group:Oral Fecal Microbiota Capsules
Control group:Conventional Therapy
Sponsors
923 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65 years old. 2.Meet the DSM-5 diagnostic criteria for schizophrenia and related psychiatric disorders; have been taking antipsychotics such as clozapine regularly for =2 weeks, and constipation is confirmed to be associated with antipsychotic medication. 3.Stable psychiatric condition and able to comply with follow-up. 4.Signed informed consent (by the subject themselves or their legal guardian).
Exclusion criteria
Exclusion criteria: 1.Constipation caused by organic intestinal diseases (intestinal obstruction, tumor, inflammatory bowel disease, etc.). 2.Presence of contraindications to fecal microbiota transplantation (FMT), including severe immunodeficiency, severe infection, and hypersensitivity to FMT capsules. 3.Complicated with severe hepatic or renal insufficiency and cardiovascular diseases. 4.Received treatment with probiotics, antibiotics or microecological preparations within the past 3 months. 5.Pregnant or lactating women. 6.Unable to cooperate and complete follow-up assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bristol Stool Form Scale score;Weekly number of complete spontaneous bowel movements;Wexner Constipation Severity Score; | — |
Countries
China
Contacts
Public ContactYan Geng
923 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army
Outcome results
None listed