Exocrine Pancreatic Insufficiency
Conditions
Interventions
Pancreatic enzyme replacement therapy group:The dosage will be individualized based on the patient's dietary fat content, typically 25,000–40,000 U of lipase taken with meals.
Control group:None
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years old, regardless of gender. 2. Pathologically confirmed gastric adenocarcinoma and having undergone radical resection surgery (including total gastrectomy, proximal gastrectomy or distal gastrectomy). 3. Smooth postoperative recovery and resumption of oral feeding. 4. Undergone assessment of pancreatic exocrine function within 1 to 3 months after surgery and meeting at least one of the following criteria: (1)Fecal elastase-1 (FE-1) test value < 200 µg/g. (2) Abnormal result of ¹³C-mixed triglyceride breath test. 5. Fully understand this study and voluntarily sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of definite chronic pancreatitis, pancreatic resection surgery or biliary diseases affecting pancreatic function. 2. Concurrent severe heart, liver or kidney dysfunction or hematological diseases. 3. Women in pregnancy or lactation. 4. Presence of severe gastrointestinal obstruction or inability to tolerate oral medication due to other reasons. 5. Suffering from mental disorders or judged by the researcher to have poor compliance and likely unable to complete the study process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin;Serum albumin; | — |
Countries
China
Contacts
Public ContactZhibo Yan
Qilu Hospital of Shandong University
Outcome results
None listed