Chronic Kidney Disease
Conditions
Interventions
Ad libitum feeding group (control group):Maintain your original eating habits and eat freely
Time-restricted feeding group (TRF group):Time-limited meal intake (16+8 mode)
Anti-inflammatory diet group (AID group):Anti-inflammatory diet
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with CKD stage 1-2 (eGFR=60ml/min/1.73m2) who meet the diagnostic criteria for CKD defined by the KDIGO Clinical Practice Guidelines for Chronic Kidney Disease and who have any of the following: (1) patients with central obesity (waist circumference >=90cm in men and >=85cm in women); (2) combined with overweight (>=24kg/m^2, and =28kg/m^2); 2. proteinuria =18 years old, <=60 years old; No gender limit
Exclusion criteria
Exclusion criteria: 1. Diagnosis of type 2 diabetes or type 1 diabetes; Patients with acute kidney injury/recent fluctuation of serum creatinine (a 30% increase in serum creatinine within 3 months or a decrease in eGFR to > 50% of baseline); 3. Autoimmune glomerular diseases; 4. Participants who had undergone or expected to undergo invasive procedures such as renal biopsy during the study period; (5) During the study period, the control group took the initiative to implement the research interventions such as time-restricted eating (TRF) or anti-inflammatory eating pattern (AID), which resulted in the inconsistency between the actual intervention and the grouping; 6. Use of glucocorticoids, systemic immunosuppressants (including and not limited to mycophenolate mofetil, calcineurin inhibitors, cyclophosphamide, azathioprine, etc.) within three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Composition Analysis;Body Weight;Waist Circumference;Renal Oxygenation and Diffusion Function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Omics Analysis;Urinary Omics;Fecal Microbiota Analysis; | — |
Countries
China
Contacts
Public ContactLing Li
West China Hospital, Sichuan University
Outcome results
None listed