perioperative neurocognitive disorders
Conditions
Interventions
Experimental group:Propofol was used for anesthesia induction and maintenance. The induction dose of propofol was 2 mg/kg, and the maintenance dose ranged from 4 to 10 mg/kg/h.
control group:Ciprofol was used for anesthesia induction and maintenance. The induction dose of ciprofol was 0.4 mg/kg, and the maintenance dose ranged from 0.8 to 1.5 mg/kg/h.
Sponsors
Xuzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients scheduled to undergo knee or hip arthroplasty; 2. Age >= 65 years; 3. BMI: 18–30 kg/m²; 4.ASA physical status I–III; 5. MMSE score: >17 for illiterate subjects, >20 for those with primary school education, and >24 for those with junior high school education or above; 6.Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with central nervous system diseases (e.g. stroke, dementia, etc.) or psychiatric disorders; 2. Patients on long-term use of medications affecting the nervous or psychiatric system; 3. Patients with severe impairment of vision, hearing, or language expression; 4. Patients with a history of severe brain tumors or brain surgery; 5.Patients with severe cardiac, pulmonary, hepatic, or renal dysfunction; 6. Patients with known allergies to the study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| perioperative neurocognitive disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| plasma inflammatory cytokine levels;incidence of postoperative nausea and vomiting ;quality of postoperative recovery;incidence of propofol- and ciprofol-associated injection pain;incidence of intraoperative hypotension and bradycardia; | — |
Countries
China
Contacts
Public ContactGao Fang
Xuzhou Medical University Affiliated Hospital
Outcome results
None listed