Recurrent implantation failure in frozen embryo transfer cycles
Conditions
Interventions
Experimental group:Luteal support + low molecular weight heparin
Sponsors
The Second Hospital, Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: 1. Egg retrieval age = 4BC; 4. At least 3 attempts of fresh/frozen embryo transfer have failed; 5. Participants are willing to cooperate with the research plan and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. One of the spouses has chromosomal abnormalities; 2. Un-treated submucosal uterine fibroids or endometrial polyps; 3. History of autoimmune diseases, such as antiphospholipid syndrome, Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, etc.; 4. Thin endometrium before transplantation (< 7mm); 5. Medical contraindications for LMWH or ART and/or pregnancy; 6. Women currently taking any anticoagulant drugs (such as aspirin); 7. History of intrauterine adhesions; 8. Ultrasound showing untreated tubal hydrops; 9. Embryos to be thawed and transplanted come from frozen stored oocytes sources, or have undergone secondary freezing storage; 10. History of recurrent spontaneous abortion (RSA); 11. FET after pre-implantation genetic testing (PGT).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Biochemical pregnancy rate;Embryo implantation rate;Early miscarriage rate;Ectopic pregnancy rate;Complication rate during pregnancy;Perinatal complication rate;Fetal birth weight;Congenital malformation;Other adverse reactions; | — |
Countries
China
Contacts
Public ContactCui Linlin
The Second Hospital, Cheeloo College of Medicine, Shandong University
Outcome results
None listed