Thyroid Surgery
Conditions
Interventions
OFA group:After arrival and monitoring, dexmedetomidine is infused intravenously with a loading dose of 1 µg/kg administered over 15 minutes, followed by a maintenance infusion at 0.2 µg/kg/h. After t
OA group:After arrival and monitoring, normal saline is infused intravenously at the same rate as the dexmedetomidine infusion, as a placebo.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~65 years; 2. BMI 18~30 kg/m^2; 3. ASA physical status I~II; 4. Patients scheduled for elective thyroidectomy under general anesthesia; 5. Normal communication ability; 6. Voluntary participation and signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Sick sinus syndrome; 2. Heart rate < 55 beats/min; 3. Second-degree or higher atrioventricular block without a pacemaker; 4. Use of antiemetics or analgesics within 24 hours before surgery; 5. Use of antipsychotics or corticosteroids; 6. History of heart failure or arrhythmia; uncontrolled hypertension; diabetes with poor glycemic control; liver or kidney dysfunction; 7. Inability to understand the Quality of Recovery-15 (QoR-15) scale and Numerical Rating Scale (NRS); 8. Allergy to the study drugs; 9. History of bleeding disorders or coagulation abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of intra-patient recovery 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores; Postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactLu Yao
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed