Obese patients
Conditions
Interventions
Control group:Propofol is used for induction and maintenance under general anesthesia
Experimental Group:General anesthesia induction and maintenance use of remimazolam
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 28 kg/m^2<= BMI <=40 kg/m^2; 2. Age: 18-65 years old, ASA classification: I - III; 3. General anesthesia surgery is planned and the operation time is expected to exceed 1 hour.
Exclusion criteria
Exclusion criteria: 1. Benzodiazepines, opioid analgesics and psychotropic drugs were taken within one month before the study; 2. Allergic to the drugs involved in the research; 3. Preoperative combined myasthenia gravis or severe liver and kidney dysfunction (defined as Child C liver function classification, creatinine clearance rate < 30ml/min).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cardiac and pulmonary complications during hospitalization;Perioperative hypotensive events; | — |
Secondary
| Measure | Time frame |
|---|---|
| The differences in the evaluation indicators of the onset speed of drug sedation between the two groups of patients;The differences in drug safety evaluation indicators between the two groups of patients;Evaluation indicators of drug metabolism rate;The differences in the assessment indicators of drug sedation intensity between the two groups of patients include; | — |
Countries
China
Contacts
Public ContactQian Li
West China Hospital of Sichuan University
Outcome results
None listed