cerebrovascular disease
Conditions
Interventions
Experimental Group 1:Cognitive Training Combined with Task-Oriented Motor Rehabilitation
Experimental Group 2:Task-Oriented Movement Training
control group:Passive Motion Training
Sponsors
Renmin Hospital, Hubei University of Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of unilateral ischemic or hemorrhagic stroke based on neuroimaging findings (cranial CT or MRI); 2. Objective evidence of post-stroke cognitive impairment, documented following the acute event; 3. Cognitive performance meeting all of the following criteria: Montreal Cognitive Assessment (MoCA) score = 21, and Clinical Dementia Rating (CDR) global score = 0.5; 4. Clinically stable and capable of tolerating and actively participating in functional near-infrared spectroscopy (fNIRS) assessment; 5. First-ever stroke episode, with time since stroke onset ranging from 2 weeks to 6 months; 6. Age between 30 and 70 years, inclusive; 7. Minimum of 6 years of formal education; 8. Right-handedness confirmed using the Edinburgh Handedness Inventory; 9. Presence of lower-limb motor dysfunction, with ambulatory capacity enabling independent or assisted walking over a distance of at least 10 meters (Functional Ambulation Category = 2).
Exclusion criteria
Exclusion criteria: 1. Individuals with disorders of consciousness, aphasia, sensorineural hearing loss, or other neurological or physical conditions that preclude reliable participation in cognitive and functional assessments; 2. Individuals with coexisting primary neurological disorders affecting the central nervous system, including but not limited to multiple sclerosis, primary or metastatic brain tumors, and neuroinflammatory conditions; 3. Individuals with dementia syndromes attributable to neurodegenerative etiologies, such as Alzheimer’s disease or dementia with Lewy bodies; 4. Individuals with a personal history of epilepsy, unprovoked seizures, febrile seizures in adulthood, or a first-degree family history of epilepsy or seizure disorders; 5. Individuals with intracranial metallic implants (e.g., aneurysm clips, deep brain stimulators), implanted electronic devices (e.g., vagus nerve stimulators), skull defects, or prior cranioplasty involving metallic materials; 6. Individuals with lower-limb musculoskeletal or neurological impairments resulting in non-ambulatory status (i.e., inability to walk =10 meters with or without assistive devices); 7. Individuals with severe cardiopulmonary, hepatic, or renal dysfunction contraindicating moderate physical activity, as determined by clinical evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Montreal Cognitive Assessment (MoCA);the Mini-Mental State Examination (MMSE);and the Clinical Dementia Rating Scale (CDR); | — |
Secondary
| Measure | Time frame |
|---|---|
| the Tinetti Mobility Test (comprising gait and balance subscales);the 6-Minute Walk Test (6MWT);the Holden Functional Ambulation Classification (FAC).; | — |
Countries
China
Contacts
Public ContactXiuli Wei
Department of Rehabilitation Medicine, Renmin Hospital, Hubei University of Medicine,
Outcome results
None listed