Dry eye syndrome
Conditions
Interventions
IPL combined with meibomian gland expression:None
Warm compress therapy combined with meibomian gland expression:None
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. individuals aged 60-80 years regardless of gender; 2. OSDI score >=13 and TBUT 3 months, with at least one characteristic symptom documented.
Exclusion criteria
Exclusion criteria: 1.Fitzpatrick skin phototypes V–VI or active infectious/specific facial skin lesions; 2. Inability to complete scheduled follow-up visits; 3. Prior IPL/Lipiflow/meibomian gland probing/punctal plug therapy within 1 year or meibomian gland expression within 2 months; 4. Active ocular surface inflammation, corneal infections/degenerative disorders, glaucoma, or significant retinal diseases; 5. Recent (within 2 weeks) topical ocular medication use (excluding artificial tears); 6. Current psychiatric treatment with long-term sedative/antidepressant medication; 7. Systemic disorders including diabetes mellitus, autoimmune diseases, or malignancies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal nerve structure indicators;Ocular Surface Disease Index (OSDI) score;Ocular Surface Pain Assessment Scale (OPAS) score;Detection of tear cytokines and neuropeptides; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of marginal eyelid morphological abnormalities;Evaluation of meibomian gland function;Corneal fluorescein staining (CFS);Tear Film Breakup Time (TBUT);Tear River Height (TMH);Meiboscore; | — |
Countries
China
Contacts
Public ContactFu Yana
Eye Hospital, Wenzhou Medical University
Outcome results
None listed