Endometrial polyps
Conditions
Interventions
Trial 1:Alfentanil group (Group A)
Modified Dixon sequential method: After 3 minutes of preoxygenation, remimazolam besylate 0.2 mg/kg was slowly administered intravenously over 60 seconds, followed b
Trial 2: Afentanil Group (AF Group):After 3 minutes of preoxygenation, administer remazolam besylate 0.2 mg/kg (IV over 60 seconds) followed by ED95 dose of alfentanil (ED95a, IV over 30 seconds). Mai
Trial 2 -Remifentanil Group (RF Group):After 3 minutes of preoxygenation, administer ED95 dose of remifentanil (ED95r) via infusion pump (infusion over 60 seconds), concurrently with remazolam besylat
Sponsors
Guabgzhou First People‘s Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I or grade II; 2. age ranged from 18 to 64 years; 3. Mouth opening >= 2.5cm; 4. Normal range of motion of head and neck; 5. Mallampati grade I or II;
Exclusion criteria
Exclusion criteria: 1. Body mass index > 30 kg/m^2 or < 18.5 kg/m^2; 2. Breastfeeding or pregnancy; 3. Severe liver disease; 4. Neuromuscular disorders; 5. Mental illness; 6. Metabolic diseases; 7. Drug or alcohol abuse; 8. The patient has contraindications for the use of benzodiazepines, sevoflurane, opioids, or dextran 40 (including a history of allergic reactions to these drugs); 9. Acute narrow angle glaucoma; 10. Shock or coma; 11. genetic diseases such as lactose intolerance, lactase deficiency, and glucose lactose malabsorption; 12. History of gastroesophageal reflux disease; 13. Acute upper respiratory tract infection; 14. Upper respiratory tract obstruction; 15. Long term use of sedatives or analgesics;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laryngeal mask airway insertion success or failure;Discharge time after hysteroscopic day surgery (defined as time from end of surgery to Post-Anesthesia Discharge Scoring System [PADSS] score >=9); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum and minimum mean arterial pressure and heart rate values from administration of remazolam or remifentanil to 5 minutes after laryngeal mask airway insertion;Time to loss of consciousness (LOC) and duration of apnea;Patient's bispectral index (BIS) value immediately before laryngeal mask airway insertion and adverse events during induction and insertion (including spontaneous breathing, breath-holding, stridor, or lacrimation);Postoperative recovery room follow-up for intraoperative awareness, nausea and vomiting, sore throat, and visual analog scale (VAS) score after awakening;Time to recovery of spontaneous breathing, adequate ventilation, response to verbal commands, laryngeal mask removal, recovery room stay duration, and time to ambulation;Surgical duration, anesthesia duration, satisfaction with anesthesia quality assessed by surgeon and patient, postoperative visual analog scale (VAS) score;Total number of intraoperative dose adjustments due to inadequate or excessive anesthesia depth per patient;All adverse events occurring during the trial period (including hypotension/hypertension, bradycardia/tachycardia, laryngospasm, hypoxemia, postoperative nausea and vomiting, hiccups, and intraoperative awareness); | — |
Countries
China
Contacts
Public ContactCheng Aobing
Guabgzhou First People‘s Hospital
Outcome results
None listed