bullous pemphigoid
Conditions
Interventions
Recurrence group and non-recurrence group:NA
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Men and women aged 18 years or above. 2. Patients diagnosed with bullous pemphigoid in the Department of Dermatology, Peking University First Hospital from January 1, 2019 to December 31, 2023. Clinical manifestations: patients had clinical features of bullous pemphigoid, multiple itchy erythema and urticaria on the skin, multiple tension bullae and erosions. Histopathology: typical findings are subepidermal blisters, dermal inflammatory infiltrates with eosinophils and monocytes. In non-bullous or atypical patients, subepithelial cleft and/or eosinophilic spongy edema. Immunofluorescence: Direct immunofluorescence showed IgG and/or C3 (and less commonly other Ig classes) deposited along the epidermal basement membrane zone. Indirect immunofluorescence showed that anti-basement membrane zone antibody IgG or rare IgA and IgE antibodies bound to the epidermal side of salt-split skin of normal subjects. Autoantibodies: anti-BP180 and/or anti-BP230 antibodies were positive in serum detected by ELISA. The diagnosis of bullous pemphigoid can be made if one or more of the histopathological, immunofluorescence, and autoantibody features meet the characteristics of bullous pemphigoid, with or without typical clinical manifestations. 3. Patients volunteered to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Minor patients under the age of 18 years. 2. Combined with other autoimmune diseases. 3. Use other biological agents and cannot be discontinued. 4. Patients who have not been regularly followed up for at least 2 years in the Department of Dermatology at Peking University First Hospital after self initiated treatment with pembrolizumab for BP.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate;Relapse rate; | — |
Countries
China
Contacts
Public ContactMingyue Wang
Peking University First Hospital
Outcome results
None listed