Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Group of Chronic Obstructive Pulmonary Disease:None
Control group:None
Sponsors
Yan'An hospital of Kunming City
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 40 years, with typical respiratory symptoms such as chronic cough, sputum production, and dyspnea; 2.According to the 2024 Global Initiative for Chronic Obstructive Lung Disease (GOLD) diagnostic criteria, post-bronchodilator FEV1/FVC < 70%; 3.Willing to participate in this study, having signed an informed consent form, and able to cooperate in completing bronchoalveolar lavage, pulmonary function tests, and related follow-ups;
Exclusion criteria
Exclusion criteria: 1.Combined with other diseases affecting lung function, such as interstitial lung disease, bronchial asthma, tuberculosis, malignant lung tumors, etc; 2.Use of immunosuppressants or systemic glucocorticoids (at a dose exceeding prednisone 10mg/day) within the past 3 months; 3.Presence of severe functional failure in vital organs such as the heart, liver, or kidneys; 4.Pregnant or breastfeeding women; 5.Presence of mental illness or cognitive impairment, unable to cooperate with the research process; 6.Recent (<=1 month) occurrence of acute exacerbation or receipt of mechanical ventilation treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LC3 - II/?; | — |
Secondary
| Measure | Time frame |
|---|---|
| Beclin - 1; PINK1/Parkin;LC3; IL-6; TNF-a; | — |
Countries
China
Contacts
Public ContactZhou Xian
Yan'An hospital of Kunming City
Outcome results
None listed