Hyperuricemia
Conditions
Interventions
Control group:Keep their daily dietary habits as usual
Interventional group:Time-restricted eating
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily sign the informed consent form; 2.Aged between 18 and 35 years; 3.Meet the diagnostic criteria for hyperuricemia as defined in the 2019 Chinese Guidelines for the Diagnosis and Management of Hyperuricemia and Gout: fasting serum uric acid levels greater than 420 µmol/L on two separate occasions; 4.Gender: both male and female are eligible; 5.Able to adhere to the study or follow-up procedures;
Exclusion criteria
Exclusion criteria: 1.Use of antibiotics or antifungal drugs within 30 days prior to enrollment; 2.Use of probiotic products within 2 weeks prior to enrollment; 3.Use of medications that may interfere with glucose or lipid metabolism within 1 month prior to enrollment (such as insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.); 4.Coexisting diseases affecting glucose/lipid metabolism or gut microbiota (e.g., thyroid dysfunction, asthma, diarrhea, inflammatory bowel disease, irritable bowel syndrome, history of gastrointestinal surgery, etc.); 5.Pregnant or lactating women; 6.Secondary hyperuricemia due to tumors, chronic kidney disease, hematologic diseases, psoriasis, medication, or other causes; 7.Hepatic insufficiency: alanine aminotransferase and/or aspartate aminotransferase >1.5 times the upper limit of normal and/or total bilirubin exceeding the upper limit of normal; 8.Renal insufficiency: estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m², calculated using the CKD-EPI equation based on the subject’s serum creatinine level; 9.Deemed unsuitable for participation in this study by the investigator’s judgment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota after 4-week of time-restricted eating; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose after 4-week of time-restricted eating;Serum uric acid after 4-week of time-restricted eating;Blood lipids after 4-week of time-restricted eating; | — |
Countries
China
Contacts
Public ContactHe Yi
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed