COPD
Conditions
Interventions
pre-COPD:None
Sponsors
Zhujiang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age: 40–80 years; (2) Individuals with pre-COPD should meet the definition of pre-COPD: presence of chronic respiratory symptoms, structural lung abnormalities (emphysema), or respiratory physiological abnormalities (preserved ratio impaired lung function, reduced DLCO, or rapid decline in FEV1 over a short period), with a post-bronchodilator FEV1/FVC >= 0.7; individuals with COPD should have a post-bronchodilator FEV1/FVC < 0.7; (3) Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Respiratory tract infection or acute exacerbation within 4 weeks prior to screening; (2) Cardiac events (myocardial infarction, malignant arrhythmia) within 3 months prior to screening; (3) Hospitalization due to heart disease within 1 month prior to screening; (4) Thoracic, abdominal, or ocular surgery within 3 months prior to screening; (5) Newly diagnosed and actively treated malignancy; (6) History of lobectomy; (7) Active pulmonary tuberculosis or currently taking anti-tuberculosis medications; (8) Mental disorders, visual hallucinations, auditory hallucinations, or use of antipsychotic medications; (9) Cognitive impairment, including dementia; (10) High-level paraplegia; (11) Pregnant or breastfeeding women; (12) BMI > 35 (to facilitate CT examination).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spirometry pre- and post-bronchodilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute Exacerbation Assessment; | — |
Countries
China
Contacts
Public ContactXin Chen
Zhujiang Hospital, Southern Medical University
Outcome results
None listed