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High-Sensitivity SERS Diagnosis and Accurate Stratification of Pediatric Caries and Pulpal/Periapical Diseases Using AuNO@AgNC Nanostructures and a Transformer Neural Network

High-Sensitivity SERS Diagnosis and Accurate Stratification of Pediatric Caries and Pulpal/Periapical Diseases Using AuNO@AgNC Nanostructures and a Transformer Neural Network

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121778
Enrollment
Unknown
Registered
2026-04-02
Start date
2026-04-02
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries and pulpal/periapical diseases in children

Interventions

Gold Standard:The gold standard for differentiating dental caries (particularly early-stage and deep caries), pulpitis, and periapical periodontitis includes histopathological examination, imaging exa
Index test:Materials Science Methods: Synthesize and characterize AuNO@AgNC nanostar@nanocube heterostructures to ensure their SERS enhancement effect and biocompatibility. Spectroscopy Methods: Esta

Sponsors

School and Hospital of Stomatology, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 10 Years

Inclusion criteria

Inclusion criteria: 1.No dental caries in the child's oral; 2.Only incipient caries present; 3.Only deep caries present; 4.Only periapical periodontitis present; 5.Only pulpitis present;

Exclusion criteria

Exclusion criteria: 1.Multiple bacterial infectious diseases in the child's oral;

Design outcomes

Primary

MeasureTime frame
Disease diagnosis classification;Accuracy;

Secondary

MeasureTime frame
Sensitivity;Specificity;

Countries

China

Contacts

Public ContactXu Zhaonan

School and Hospital of Stomatology, Wenzhou Medical University

645007015@qq.com+86 577 8806 3016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026