Postoperative pain
Conditions
Interventions
Nalbuphine Group:Nalbuphine postoperative analgesia
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 65 - 85 years old; 2. Total hip replacement surgery under elective general anesthesia; 3. ASA classification: II - III; 4. No communication disorder, clear consciousness; 5. BMI: 18.5 - 28 kg/m^2; 6. Voluntary use of postoperative intravenous analgesia device; 7. Compliant with ethics, the patient voluntarily participates and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to opioids or study drugs. 2. Those with severe liver or kidney dysfunction, history of asthma or chronic obstructive pulmonary disease. 3. Those who have been taking opioids for a long time or have a history of drug abuse. 4. Those with severe gastric ulcers, coagulation dysfunction or surgical site infections. 5. Those with language disorders or mental illnesses who are unable to communicate. 6. Those who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event;The incidence of postoperative nausea and vomiting within three days after the operation;The incidence rate of postoperative delirium (POD) within three days after surgery;The NRS scores at 48 hours and 72 hours after the operation; | — |
Countries
China
Contacts
Public ContactYu Qi
Xuzhou Central Hospital
Outcome results
None listed