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A retrospective study on the efficacy and safety of fluconazole, echinocandins, and amphotericin B deoxycholate in the treatment of candiduria in adults

A retrospective study on the efficacy and safety of fluconazole, echinocandins, and amphotericin B deoxycholate in the treatment of candiduria in adults

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121772
Enrollment
Unknown
Registered
2026-04-02
Start date
2026-04-03
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

candiduria

Interventions

fluconazole group:NA
echinocandins group:NA
amphotericin B deoxycholate group:NA

Sponsors

Huashan Hospital Affiliated to Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age >=18 years. 2. Both males and females were eligible. 3. Hospitalized patients at Huashan Hospital between January 2021 and December 2025. 4. Patients meeting the following criteria: (1) Presence of at least one clinical symptom or sign of urinary tract infection, including dysuria, urinary frequency, urinary urgency, painful urination, or lower abdominal pain; (2) Evidence of pyuria/leukocyturia confirmed by at least one of the following: a. >=5 white blood cells (WBCs) per high-power field (HPF) in centrifuged urine; b. >=10 WBCs/µL in uncentrifuged urine; c. Positive leukocyte esterase on urine dipstick testing; (3) Positive midstream clean-catch urine culture for Candida species with a colony count >=105 CFU/mL. 5. For patients with multiple hospitalizations, only data from the first hospitalization were included.

Exclusion criteria

Exclusion criteria: 1. Patients with asymptomatic candiduria; 2. Patients with concomitant Candida infections at other sites (except candidemia); 3. Patients with incomplete or missing clinical data; 4. Patients who received antifungal therapy for <48 hours.

Design outcomes

Primary

MeasureTime frame
clinical response rate;

Countries

China

Contacts

Public ContactYing Li

Huashan Hospital Affiliated to Fudan University

ying_lihs@fudan.edu.cn+86 21 5288 8195

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026