post-stroke cognitive impairment
Conditions
Interventions
iTBS Group:Intermittent theta burst stimulation (iTBS): stimulation of the affected dorsolateral prefrontal cortex (F3/F4), intensity at 80%-100% of motor threshold, intra-burst frequency of 50Hz, int
MNES Group:Median nerve electrical stimulation (MNES): P14 mode, frequency 40Hz, pulse width 300µs, initial intensity 14mA. Applied to the medial side of the right wrist (within 5cm range of the wrist
Combined Intervention Group:First administer median nerve electrical stimulation (MNES), followed by intermittent theta burst stimulation (iTBS). Combined with conventional rehabilitation and cognitiv
Sham Stimulation Group:Sham iTBS: the coil is rotated 90° so that the side of the coil contacts the scalp (patients hear noise but no effective stimulation is delivered). Combined with conventional re
Sponsors
Xuzhou Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of stroke meets the diagnostic criteria outlined in 2019 by the Neurology Branch of the Chinese Medical Association, the Cerebrovascular Disease Group of the Neurology Branch of the Chinese Medical Association, and the diagnostic criteria for various major cerebrovascular diseases in China. 2. Age range from 40 to 80 years old, all underwent cranial CT and MRI examinations. 3. After MoCA screening, a score of <26 was diagnosed as cognitive impairment with a course of less than 1 year. 4. Having sufficient visual and auditory discrimination to undergo neuropsychological tests and various cognitive assessments. 5. Approved by the ethics committee, the subjects and/or guardians have informed consent and signed a consent form.
Exclusion criteria
Exclusion criteria: 1. Exclude patients with a history of other brain diseases, such as traumatic brain injury, progressive supranuclear palsy, epilepsy, chronic subdural hematoma, Huntington's disease, normal pressure hydrocephalus, brain infection, brain tumor, or known brain structural abnormalities. 2. Exclude patients with a history of neurodegenerative diseases, congenital or hereditary diseases. Excluding cognitive impairment caused by cerebrovascular factors such as AD, Parkinson's disease, and Louis body dementia. 3. Exclude patients with cognitive impairment caused by liver, kidney, thyroid, and other systemic diseases, anemia, malnutrition, and other reasons. Excluding patients with consciousness disorders, severe neurological deficits, inability to take care of themselves, and severe dementia who are unable to complete the scale test. 4. (1) Excluding patients who are unable to complete the scale test due to hearing, vision, and language impairment, as well as those who have a history of alcohol or drug abuse or dependence on alcohol or drugs within the past 2 years. 5. Excluding pseudodementia caused by various other reasons. 6. Researchers believe that subjects who cannot comply with the research procedure. 7. Intracranial metal implants, magnetic films, pacemakers, etc. 8. Personal or family history of epilepsy and mental illness (including febrile seizures during infancy). 9. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lohman Occupational Therapy Cognitive Assessment (LOTCA) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ratio of N-acetylaspartate to creatine (NAA/Cr) and choline to creatine (Cho/Cr) in the brain assessed by 1H-MRS;P300 Latency and Amplitude Measured by Auditory Oddball Paradigm;Relative Power Ratio in EEG Frequency Bands; | — |
Countries
China
Contacts
Public ContactWang Shiyany
Xuzhou Rehabilitation Hospital
Outcome results
None listed