None
Conditions
Interventions
Experimental group:Target-controlled infusion (TCI) of haloperidol combined with intravenous sufentanil and remimazolam
Sponsors
The Affiated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45–65 years, regardless of gender; 2. BMI between 18.5 kg/m^2 and 30 kg/m^2; 3.American Society of Anaesthesiologists (ASA) classification of Class I–III; 4. Patients scheduled for elective non-cardiac thoracic surgery under general anaesthesia with double-lumen endotracheal intubation; 5. Preoperative cardiac function assessment: New York Heart Association (NYHA) functional class I–II; transthoracic echocardiography showing a left ventricular ejection fraction (LVEF) >= 50%; 6. Patients voluntarily participate in this study and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with allergies to cyclopentolamine, sufentanil, remimazolam, soya or eggs; 2. Pre-anaesthetic heart rate 100 beats per minute; 3. History of severe cardiovascular disease, such as unstable angina, myocardial infarction within the past 6 months, severe arrhythmias (e.g. third-degree atrioventricular block, uncontrolled ventricular tachycardia), severe valvular heart disease, or poorly controlled hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg); 4. Severe hepatic or renal impairment (Child-Pugh class B or C; or estimated glomerular filtration rate = grade III); 6. Long-term use of medications that affect cardiovascular responses or the metabolism of anaesthetics, such as: a/ß-blockers, calcium channel blockers (except for those who have taken them regularly for >=3 months prior to surgery and at a stable dose for >=1 month), potent CYP enzyme inhibitors or inducers, antipsychotic drugs, etc.; 7. Use of sedatives or analgesics within 24 hours prior to surgery; 8. The planned surgery is an emergency procedure, or the investigator determines that any other condition exists that renders the subject unsuitable for participation in this study (e.g. mental illness, communication difficulties, history of drug or alcohol abuse); 9. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gradient changes of target concentration in the effect compartment of ciprofol TCI;Cardiovascular response to endotracheal intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators (Mean Arterial Pressure, Heart Rate, Systolic Blood Pressure);Frequency of administration of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactChen Long
The Affiated Cancer Hospital of Guizhou Medical University
Outcome results
None listed