Major Depressive Disorder
Conditions
Interventions
Nucleus Accumbens Treatment Group:Temporal Interference Stimulation of Nucleus Accumbens
Subgenual Anterior Cingulate Cortex Treatment Group:Temporal Interference Stimulation of Subgenual Anterior Cingulate Cortex
Ventromedial Prefrontal Cortex Treatment Group:Temporal Interference Stimulation of Ventromedial Prefrontal Cortex
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–55, regardless of gender; 2. Meeting the diagnostic criteria for depressive disorders according to DSM-5; 3. Moderate or severe depression severity (total score of 17-item HAMD >= 18 and <= 35; 4. Anhedonia (total DARS score <= 28); 5. No physical therapies such as ECT or rTMS received in the past 6 months; 6. Antidepressant regimen remains unchanged from 30 days before signing the informed consent until the trial period. If the patient is currently using more than 2 antidepressant drugs or an antidepressant + augmenting agent combination, the regimen must be adjusted to <= 2 antidepressant agents within 1 week before enrollment; 7. Having completed at least primary school education or above, with adequate visual, auditory, and comprehension abilities;
Exclusion criteria
Exclusion criteria: 1. Presence of significant somatic diseases, such as cardiovascular or cerebrovascular diseases, respiratory system diseases, hepatic or renal diseases, malignant tumors, etc; 2. Meeting diagnostic criteria for other DSM-5 mental disorders, including personality disorders or intellectual disability; 3. Drug and/or alcohol dependence; 4. History of epilepsy; 5. Individuals with suicidal tendencies or a history of suicidal behavior; 6. Patients with extremely severe depression (total score of 17-item HAMD > 35); 7. Pregnant or lactating women; 8. Any other condition that, in the investigator’s judgment, may affect the completion of follow-up in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression Severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anhedonia Severity;Brain Electrical Activity;Cognitive Founction;Anxiety Severity;Brain Structures and Function; | — |
Countries
China
Contacts
Public ContactJitao Li
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed