Elderly infertile women
Conditions
Interventions
non-invasive chromosome genetic screening (NICS) group:None
Preimplantation Genetic Testing for Aneuploidy (PGT-A) group:None
Sponsors
Hebei Maternity Hospital
Eligibility
Sex/Gender
Female
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 40 years. 2. Normal karyotype in both partners and normal sex hormone levels: FSH < 12 IU/L, E2 < 80 pg/ml. 3. Body Mass Index (BMI): 18–28 kg/m². 4. Intracytoplasmic Sperm Injection (ICSI) as the fertilization method. 5. Compliance with national family planning policies. 6. Signed informed consent form. 7. Agreement to undergo elective freeze-thaw single embryo transfer. 8. Willingness to comply with the study protocol and ability to complete the study.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to IVF/ICSI treatment. 2. Uterine malformations. 3. Severe intrauterine adhesions or an endometrial thickness of <7 mm. 4. Endometriosis (Stage III–IV). 5. Coexisting systemic diseases such as hypertension, diabetes mellitus, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cumulative live birth rate;multiple pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| cumulative clinical pregnancy rate;fetal malformation rate;cumulative ongoing pregnancy rate;implantation rate;cumulative biochemical pregnancy rate;cumulative early miscarriage rate; | — |
Countries
China
Contacts
Public ContactXiaoxi Li
Hebei Maternity Hospital
Outcome results
None listed