Subthreshold depression
Conditions
Interventions
Group 1:Mindfulness meditation
Group 2:Casual care
Sponsors
The School of Medicine, Yunnan University
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-30 years; 2. Patient Health Questionnaire-9 (PHQ-9) score >=5 and Beck Depression Inventory-II (BDI-II) score >=14. 3. Normal systolic and diastolic blood pressure. 4. Body Mass Index (BMI) <= 28 kg/m². 5. Able to attend weekly Saturday sessions for 8 weeks and engage in daily practice on weekdays. 6. No current use of psychoactive medications and no history of substance dependence. 7. No prior meditation or mindfulness training within the past 3 months. 8. Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe neurological disorders, bipolar disorder, intellectual disability, other psychiatric disorders, or substance abuse history (alcohol, psychoactive substances, CNS stimulants). 2. Major physical diseases or hyperhomocysteinemia-related conditions (hypertension, diabetes mellitus, chronic renal/hepatic failure). 3. Current/recent use of homocysteine-affecting medications (vitamin B6, folic acid, vitamin B12, related supplements). 4. History of regular smoking, alcohol consumption, or chronic tea/coffee drinking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of depressive symptoms;Verbal Fluency Task;Resting state Functional Connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of depressive symptoms;Change of anxiety symptoms;Change of insomnia symptoms;Change of mindfulness level;Change of rumination; | — |
Countries
China
Contacts
Public ContactKeming Zhu
The School of Medicine, Yunnan University
Outcome results
None listed