Coronary artery stenosis
Conditions
Interventions
A Group (Standard Protocol Group):None
B Group (Optimized Protocol Group):None
Sponsors
Guiqian International Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80; 2. Clinically suspected coronary heart disease and evaluated by the attending physician as meeting the indications for routine CCTA examination, this examination is planned to be performed. 3. The subjects were fully informed of the research content, the core differences between the two scanning protocols, and the potential risks and benefits. 4. One can independently choose the examination plan without the intervention of researchers. 5. Be able to understand and voluntarily sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. There is a history of severe allergy to iodine contrast agents; 2. Uncontrolled hyperthyroidism; 3. Decompensated heart failure (NYHA grade IV) or hemodynamic instability; 4. Severe arrhythmias such as persistent atrial fibrillation; 5. End-stage renal disease (eGFR 1000); 8. Other circumstances where the researcher deems it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary image interpretability (percentage of segments with score >=3 out of total evaluated segments per patient); | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiation dose metrics (volume CT dose index CTDIvol, dose-length product DLP, effective dose ED);Contrast agent-related metrics (total iodine contrast volume, injection rate);Objective image quality metrics (CT attenuation values, image noise SD, signal-to-noise ratio SNR, contrast-to-noise ratio CNR in the ascending aortic root and major coronary artery branches);Diagnostic performance metrics (sensitivity, specificity, positive predictive value PPV, negative predictive value NPV, area under the ROC curve AUC); | — |
Countries
China
Contacts
Public ContactMeng Xiao
Guiqian International Hospital
Outcome results
None listed