Feeding intolerance
Conditions
Interventions
low-dose erythromycin group:Thirty minutes before the patient is indwelled with a spiral nasoenteric tube, 50 ml of erythromycin injection (containing 500 mg of erythromycin) is administered. After su
standard-dose erythromycin group:Thirty minutes before the patient is indwelled with a spiral nasoenteric tube, 50 ml of erythromycin injection (containing 500 mg of erythromycin) is given. After succ
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Admitted to the ICU; 3. Requires enteral nutrition support; 4. Large gastric residual volume (single measurement > 150 ml or cumulative volume over 12 hours > 500 ml); 5. The informed consent form has been signed.
Exclusion criteria
Exclusion criteria: 1. Those with indications for percutaneous gastrostomy or jejunostomy; 2. Esophageal varices or stenosis, or those who have undergone major gastric-esophageal surgeries such as esophagectomy or gastrectomy; 3. Active upper gastrointestinal bleeding; 4. Severe nasopharyngeal injuries or stenosis; 5. Severe coagulation dysfunction; 6. Gastric malignancy, peptic ulcer or mechanical intestinal obstruction; 7. Pregnancy; 8. Those who are contraindicated for using erythromycin; 9. Those who are allergic to meglumine diatrizoate; 10. Those who have used prokinetic drugs (including erythromycin, metoclopramide, etc.) within 48 hours before enrollment; 11. Those who are participating in other drug clinical trials; 12. Any other conditions that the researcher deem unsuitable for participating in the clinical trial (such as increasing the risk to the subjects or possibly interfering with the judgment of the study endpoints, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the 24 hours success rate of post-pyloric placement of spiral nasoenteric tubes; | — |
Secondary
| Measure | Time frame |
|---|---|
| After 24 hours of catheter placement, the proportion of the tube entering the second and third segments of the duodenum and the proximal jejunum; | — |
Countries
China
Contacts
Public ContactChunbo Chen
Shenzhen People's Hospital
Outcome results
None listed