melasma
Conditions
Interventions
Experimental group:Fog cannon assists transcutaneous delivery of tranexamic acid
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The age of the study participants is 35-60 years old, including 35 and 60 years old, regardless of gender; 2. Melasma on the face, manifested as benign pigmented diseases or flushing, and is in a stable period; 3. Agree not to change the routine cleansing and basic moisturizing skin care routine throughout the trial, and stop using functional skin care products containing whitening ingredients (such as hydroquinone, vitamin C and its derivatives, arbutin, etc.) or affect pigment metabolism and photosensitivity or receive laser, photonics, acid brushing and other treatments during the trial and within one month before the trial; 4. Agree to strictly protect from the sun during the trial and for 1 month before and after the trial; 5. Promise to complete the whole course of treatment and follow-up according to the trial plan; 6. Previous traditional treatment methods (topical drugs, lasers, etc.) are not effective.
Exclusion criteria
Exclusion criteria: 1. Facial pigmentation is suspected to be malignant or the nature is not yet clear; 2. Pregnant women, lactating women, or women who have a pregnancy plan within six months after the end of the study; 3. Participate in other clinical studies of facial rejuvenation during the study period; 4. Combined with other skin diseases or excessive hair that significantly affect the evaluation of skin color; 5. Known allergy to the skin functional drugs or saline components used in the test; 6. Received any laser, intense pulsed light or chemical peeling treatment for pigmentation in the past 3 months; 7. Presence of skin breakage, wounds, active inflammation, or infection in the treatment area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of decrease in MASI score after the end of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| GAIS score;Pain Score;Satisfaction; | — |
Countries
China
Contacts
Public ContactYao Min
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed