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Prospective, paired, single-center diagnostic trial of S100 immunohistochemistry combined with HE staining versus HE staining alone in the detection rate of perineural invasion in postoperative pathology of stage I–III colon cancer

Prospective, paired, single-center diagnostic trial of S100 immunohistochemistry combined with HE staining versus HE staining alone in the detection rate of perineural invasion in postoperative pathology of stage I–III colon cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121709
Enrollment
Unknown
Registered
2026-04-01
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stage I–III colon cancer

Interventions

Gold Standard:Hematoxylin and Eosin Staining
Index test:S100 immunohistochemistry combined with HE staining

Sponsors

Fifth Affiliated Hospital, Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Pathologically confirmed stage I–III colon adenocarcinoma; 2.Underwent radical surgical resection (R0 resection); 3.Aged 18–70 years (inclusive); 4.Complete clinicopathological data available;

Exclusion criteria

Exclusion criteria: 1.Rectal cancer (distance from anal verge 48 hours); 5.Presence of distant metastasis (M1); 6.Received neoadjuvant therapy preoperatively;

Design outcomes

Primary

MeasureTime frame
Difference in the detection rate of perineural invasion (PNI) in postoperative pathology of stage I-III colon cancer between S100 immunohistochemistry combined with HE staining and HE staining alone;Accuracy;—

Secondary

MeasureTime frame
Sensitivity;Specificity;—

Countries

China

Contacts

Public ContactLinjuan Zeng; Yujing Lin

Fifth Affiliated Hospital, Sun Yat-Sen University

zenglinj@mail.sysu.edu.cn+86 756 252 8027

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026