Obstructive Sleep Apnea (OSA) is characterised by sleep snoring and repeated obstruction of the upper airway leading to apnea or hypoventilation. Hypoxia, hypercapnia and hyperpnoea drive a series of pathological changes secondary to repeated sympathetic activation during sleep, microarousal and disruption of sleep architecture, chronic intermittent hypoxia, leading to neurocognitive impairments,
Conditions
Interventions
Control group:None
Sponsors
Bejing Tongren Hospital, Capital Medical Uniersity
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the healthy control group: Those who meet the following criteria simultaneously were included in the study 1. 18-75 years old; 2. No OSA related symptoms; 3. No other sleep disorders, such as narcolepsy or restless legs syndrome, etc.; 4. The subjects were able to understand and sign the informed consent form and comply with the trial protocol. Inclusion criteria for the case group: Those who meet the following criteria simultaneously will be included in the study 1. 18-75 years old; 2. Due to symptoms such as snoring, breathing pauses, and daytime sleepiness, polysomnography is planned to be conducted at the sleep Medicine center; 3. The subjects were able to understand and sign the informed consent form and comply with the trial protocol.
Exclusion criteria
Exclusion criteria: Common exclusion criteria (case group and healthy control group) : Exclusion is determined if any of the following conditions are met; 1 Patients with recent upper respiratory tract infections, a history of nasal, pharyngeal, oral and maxillofacial surgeries, and language disorders; 2 Poorly controlled chronic obstructive pulmonary disease, severe cardiovascular and cerebrovascular diseases or hemodynamic instability, thyroid or pituitary dysfunction, neuromuscular diseases, uncontrolled cardiovascular and cerebrovascular and metabolic diseases, confirmed brain degenerative diseases (such as Parkinson's disease or Alzheimer's disease), history of metal implants in the head and neck and craniocerebral surgery, and heavy drinkers. 3 Exclude mental illnesses that have not been properly controlled and other situations where one cannot cooperate to complete the examination. The research plan is formulated in accordance with the principles of the Declaration of Helsinki and is implemented after being approved by the institutional review board. All participants signed written informed consent forms before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-Hypopnea Index(AHI);Skin Sympathetic Nerve Activity (SKNA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Epworth Sleepiness Scale(ESS);Psychomotor Vigilance Task(PVT);Montreal Cognitive Assessment(MoCA);Eysenck Personality Questionnaire(EPQ);Trail Making Test(TMT);Positive and Negative Affect Schedule(PANAS);Respiratory cycle and body position information;Stroop Color-Word Test(SCWT);Pittsburgh Sleep Quality Index(PSQI);Heart Rate Variability (HRV);Snoring data;A neural network for EEG and snoring signals;Self-Rating Depression Scale(SDS);Self-Rating Anxiety Scale(SAS); | — |
Countries
China
Contacts
Public ContactLi Yanru
Bejing Tongren Hospital, Capital Medical Uniersity
Outcome results
None listed