Primary monosymptomatic nocturnal enuresis
Conditions
Interventions
Gold Standard:Diagnostic criteria for primary monosymptomatic nocturnal enuresis: Age = 5 years, at least 1 episode of involuntary nocturnal urination per month for more than 3 months, without concurr
Index test:Serum copeptin detection: ELISA . Commercially available human copeptin ELISA kits were used
Urine AQP-2 detection: ELISA method. The corresponding human AQP-2 ELISA kit.Other tests: Urine specific gravity, osmotic pressure, fasting blood glucose, blood routine, urine creatinine, blood creati
Sponsors
Children's Hospital,Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: Case Group: 1. Age 5-18 years. 2. No treatment within 1 month prior to the trial. 3. Able to complete a 2-day, 7-night urination diary and study-related questionnaires. 4. Guardians and the children themselves agree to participate in the study and sign informed consent forms. 5. Meet the 2025 nocturnal enuresis guideline diagnostic criteria for PMNE: age >=5 years, at least 1 episode of involuntary urination at night per month, lasting more than 3 months, without daytime lower urinary tract symptoms or organic urinary system diseases. Healthy Control Group: 1. Children with no history of nocturnal enuresis or abnormal daytime urination, and no history of chronic kidney, endocrine, or nervous system diseases, including: normal urine routine, serum creatinine value, eGFR value, and urinary system B-ultrasound. 2. No recent acute infections, dehydration, or excessive water intake. 3. No treatment within 1 month prior to the trial.
Exclusion criteria
Exclusion criteria: 1. Patients under the age of 5; 2. Patients with daytime lower urinary tract symptoms or history of bladder dysfunction; 3. Patients with secondary nocturnal enuresis who have experienced at least 6 months of dry bed period; 4. Patients with chronic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum copeptin; ;Urine AQP-2 test;; | — |
Countries
China
Contacts
Public ContactMao Jianhua
Children's Hospital,Zhejiang University School of Medicine
Outcome results
None listed