Neuropathic pain
Conditions
Interventions
Sham group:Sham transcranial magnetic stimulation was performed after establishing the pain model.
iTBS Group:After establishing the pain model, the primary motor cortex (M1) was stimulated using the intermittent theta-burst stimulation (iTBS) mode of transcra
Sham group FMT:Fecal microbiota transplantation using fecal microbiota from Sham group volunteers
iTBS group FMT:Fecal microbiota transplantation using fecal microbiota from volunteers in the iTBS group
Healthy Group FMT:Fecal microbiota transplantation using fecal microbiota from healthy volunteers
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Right-handed; 2.Healthy adults meeting the TMS application criteria; 3.Voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Has been diagnosed with or assessed for a mental disorder using standardized scales; 2.Taking analgesics and other medications from one month before allocation until the end of the study; 3.Persistent pain of any type; 4.Any metal implants; 5.History of dysmenorrhea, menstruation, pregnancy, or lactation; 6.Used central nervous system stimulation/modulation techniques within the past 2 weeks; 7.History of gastrointestinal disease or recent gastrointestinal symptoms; 8.Has a documented history of allergic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal proteomics;Peripheral Blood Single-Cell Transcriptomics;Fecal Metabolomics;Peripheral Blood Proteomics;Peripheral Blood Metabolomics;Fecal microbiota; | — |
Countries
China
Contacts
Public ContactHanbin Wang
Hangzhou First People's Hospital
Outcome results
None listed