Postoperative delirium
Conditions
Interventions
Thiamine group:After the end of general anesthesia induction, dilute 200mg of thiamine in 100ml of saline and infuse intravenously
Saline group:After the end of general anesthesia induction, 100 ml of normal saline is administered intravenously.
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 70 years, any gender; 2. Patients planning to undergo major abdominal surgery (elective major surgery involving the gastrointestinal tract, with an expected duration of more than 90 minutes. Surgery types include colonic, rectal, or small intestine resections; pancreatic and intestinal resections; gastrectomy (non-obesity surgery); esophagectomy (non-obesity surgery); obesity surgery; and other surgeries involving intestinal resection).
Exclusion criteria
Exclusion criteria: 1. Individuals prone to allergies or known to be allergic to thiamine; 2. Those with a history of Wernicke’s encephalopathy, alcohol dependence, or long-term thiamine supplementation; 3. Those with severe dementia or a history of mental illness before surgery; 4. Patients who already show cognitive impairment in preoperative screening (Montreal Cognitive Assessment score below 26); 5. Those with vision, hearing impairments, or communication difficulties; 6. Those with severe cardiovascular disease or severe liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative delierum;Duration of postoperative delirium;Sleep score 7 days after surgery;Depression score 7 days after surgery;Anxiety score 7 days after surgery;Incidence of nausea and vomiting within 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactYu Wang
The First Hospital of University of Science and Technology of China
Outcome results
None listed