Older adults with depression
Conditions
Interventions
True Stimulation Group:Bilateral sequential TBS (left iTBS+cTBS), 80% RMT intensity, 5 times per week for 2 weeks (10 sessions)
Sham Stimulation Group:Sham stimulation (coil placed at 90° to the scalp, no effective stimulation), 80% RMT intensity, 5 times per week for 2 weeks (10 sessions)
Sponsors
The Brain Hospital of Guangxi Zhuang Autonomous Region.
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Provide informed consent; 2. Meet the diagnostic criteria for depression as outlined in the International Classification of Diseases (ICD-10) Application Manual, including first-episode or recurrent depression, regardless of gender; 3. HRSD-17 total score >= 17 points; 4. Age >= 60 years old, right-handed; 5. Complete clinical records, no antidepressant medication use within the past month; 6. Normal uncorrected or corrected visual acuity in both eyes; 7. Compliance with medical ethics committee requirements.
Exclusion criteria
Exclusion criteria: 1. History of severe physical or brain organic diseases, or history of head trauma; 2. Patients with comorbid conditions such as Alzheimer's disease or glaucoma; 3. History of drug, alcohol, or other psychoactive substance abuse; 4. Individuals with contraindications to rTMS (e.g., history of epilepsy, intracranial implants); 5. Patients with a history of manic episodes or schizophrenia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale-17 (HDRS-17) Score Reduction Rate and Remission Rate;Montgomery-Asberg Depression Rating Scale (MADRS) Score Reduction Rate and Remission Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurocognitive Function;Anxiety Symptoms; | — |
Countries
China
Contacts
Public ContactLan Xianjun
The Brain Hospital of Guangxi Zhuang Autonomous Region.
Outcome results
None listed