post-stroke cognitive impairment
Conditions
Interventions
Observation group:None
Control group:None
Sponsors
Wannan Rehabilitation Hospital of Anhui Province(The Fifth People’s Hospital of Wuhu)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Diagnosis consistent with the diagnostic criteria of Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China (2014 Edition) and confirmed by MRI/CT; 2. Standardized rehabilitation initiated within 1–3 months after onset and continued for >= 3 months, in accordance with Guidelines for Stroke Rehabilitation; 3. Age >= 18 years, conscious and able to cooperate with scale assessments and rehabilitation therapy; 4. Written informed consent voluntarily signed by the subject or his/her legal representative; 5. Expected follow-up duration >= 12 months.
Exclusion criteria
Exclusion criteria: 1. Previously diagnosed with dementia, mild cognitive impairment (MCI), or other neurodegenerative diseases; 2. Severe hepatic and renal insufficiency, malignant tumors, or infectious diseases (e.g., HIV, hepatitis B); 3.Coagulation dysfunction or autoimmune diseases (e.g., multiple sclerosis); 4. History of drug or alcohol abuse within the past 3 months; 5. Poor rehabilitation compliance (expected weekly rehabilitation frequency < 3 times), inability to complete follow-up, or refusal to provide serum samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glial Fibrillary Acidic Protein;Neurofilament Light Chain;Lymphocyte subsets;Interleukin-6;Tumor Necrosis Factor-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-Reactive Protein;Phosphorylated Tau at Threonine 217;Brain-Derived Tau;Amyloid ß-Protein;Homocysteine;Glycated Hemoglobin A1c; | — |
Countries
China
Contacts
Public ContactTao Wei
Wannan Rehabilitation Hospital of Anhui Province(The Fifth People’s Hospital of Wuhu)
Outcome results
None listed