Chronic Renal Failure
Conditions
Interventions
Trial group:Prime the dialyzer and circuit with 800-1000 ml of 0.9% sodium chloride injection to remove air
Add 12,500 units of heparin sodium to 500 ml of 0.9% sodium chloride, and perform a closed-loop circulation for 15 minutes (blood flow rate 260 ml/min)
Flush the circuit (including all branches) with 500 ml of 0.9% sodium chloride to ensure no residual heparin or air remains
During the dialysis process: No saline flush is used throughout the entire procedure.
Control group:Use 800–1000 mL of 0.9% sodium chloride injection to prime the circuit, then circulate in a closed loop for 15 minutes (blood flow rate 260 mL/min). No heparin adsorption is required.
Du
Sponsors
Pangang Group General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1.Maintenance hemodialysis patients complicated with gastrointestinal bleeding or cerebral hemorrhage; or hemodialysis patients with high-risk bleeding (gross hematuria, hematochezia, menstruation, skin/mucosal bleeding) or moderate-to-high bleeding tendencies (e.g., within 5 days before or after renal biopsy preparation, within 3 days after surgery or trauma); 2.No oral or injected hemostatic medications administered; 3.No blood transfusions or intravenous infusions administered through the dialysis circuit; 4.Vascular access in good condition, with blood flow velocity of arteriovenous fistula or catheter able to reach 200–300 ml/min; 5.Treatment modality is hemodialysis.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: 1.Patients who are uncooperative, agitated, or have psychiatric abnormalities; 2.Patients with abnormal platelet counts or coagulation function; 3.Patients with advanced malignant tumors combined with multiple organ failure; 4.Patients with a history of hemodialysis lasting less than 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dialyzer and Circuit Clotting Grading (Grade 0-3); | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment Efficiency: completion of effective dialysis duration and target ultrafiltration volume; comparison of acute complication occurrence during heparin-free dialysis; operational efficiency and saline consumption metrics.;Adverse event; | — |
Countries
China
Contacts
Public ContactYou Lihong
Pangang Group General Hospital
Outcome results
None listed