Chronic viral hepatitis B
Conditions
Interventions
Group B :polyethylene glycol interferon a-2b
Group C :60 µg hepatitis B vaccine
Group A :Pegylated interferon a-2b and 60ug hepatitis B vaccine group
Group D :Non-intervention
Sponsors
Xixi Hospital of Hangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 70 years old; 2. For newly diagnosed or previously treated patients with chronic hepatitis B: HBsAg(+)<10IU/ml,HBV DNA<10IU/ml,HBeAg(-); Or those who have been confirmed to have had chronic HBV infection in the past, and after interferon treatment, HBsAg has turned negative but HBsAb has not been produced. 3. Those who can strictly abide by the requirements of clinical trials.
Exclusion criteria
Exclusion criteria: 1. There are other causes of active liver disease, including coexisting HCV, HDV, HIV infection or autoimmune hepatitis, fatty liver; 2. Clinical manifestations of liver cirrhosis or decompensated liver diseases, including previous esophageal variceal bleeding, ascites, hepatic encephalopathy, etc. 3. Those with a history of tumors or severe or uncontrolled other systemic diseases, including heart, lung, kidney, digestive, endocrine, nervous, and mental disorders, etc. 4. Those who plan to receive organ transplants or have already undergone organ transplants; 5. Those who are allergic to pegylated interferon a-2b or any component in the vaccine, or have a history of severe allergies in the past; 6. Pregnant and lactating female patients; 7. Interferon treatment group, with neutrophil count < 2×10^9 /L and/or platelet count < 100×10^9 /L; 8. Those that the researchers consider not to meet the requirements of clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg clearance rate;HBsAg conversion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic monitoring of key indicators such as blood routine, liver function, hepatitis B three strains, HBV DNA, HBV RNA, and lymphocyte subsets.;adverse reaction; | — |
Countries
China
Contacts
Public ContactZhang Xiaojing
Xixi Hospital of Hangzhou
Outcome results
None listed