Ulcerative Colitis
Conditions
Interventions
Control group:Patients in the control group will maintain their original dietary habits, avoid spicy, greasy, raw and cold, or other irritating foods, and will not receive any special dietary interven
Experimental group:Three cycles of a fasting-mimicking diet (FMD) regimen will be implemented, with 5 consecutive days of FMD per month, and a regular light diet (avoiding spicy, greasy, raw/cold and
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 18 - 70 years old, gender not restricted; (2) Meet the diagnostic criteria for ulcerative colitis, diagnosed through colonoscopy and pathological examination; (3) The condition is in the mild-to-moderate active stage, with a modified Mayo score ranging from 2 to 8; (4) Currently receiving standard treatment with mesalazine monotherapy, with a stable medication regimen for >= 4 weeks; (5) Able to understand and cooperate with this study, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Age less than 18 years old or more than 70 years old; (2) Patients with severe active ulcerative colitis, or with severe complications such as intestinal perforation, massive bleeding, intestinal obstruction, etc.; (3) Pregnant women, lactating women, or those planning to become pregnant; (4) Known to be allergic to nuts, or with a body mass index (BMI) less than 18 kg/m^2; (5) Severely weak due to illness or medical procedures, or currently taking drugs that are contraindicated with calorie-restricted diets; (6) With diabetes and using hypoglycemic drugs that may increase the risk of hypoglycemia (such as insulin, sulfonylureas); (7) With a history of severe heart disease (uncompensated congestive heart failure NYHA grade 2 or above, left ventricular ejection fraction < 40%), syncope history, or with life-threatening malignant tumors; (8) Currently undergoing other calorie-restricted diets, or with a history of short bowel syndrome, small intestine/large intestine ostomy, total colectomy, etc. of gastrointestinal surgeries; (9) With liver or kidney dysfunction (ALT/AST more than 2 times the upper limit of normal value, serum creatinine more than 1.5 times the upper limit of normal value), which may be adversely affected by low-sugar and low-protein diets; (10) Participating in other clinical studies, or researchers consider other reasons not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Erythrocyte Sedimentation Rate;C-reactive protein;Fecal Calprotectin;Inflammatory factor;Endoscopic findings; | — |
Countries
China
Contacts
Public ContactHailong Cao
Tianjin Medical University General Hospital
Outcome results
None listed