EB encephalitis
Conditions
Interventions
Control group:N/A
EB virus encephalitis group:N/A
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary informed consent; 2. The cohort should undergo clinical examination and laboratory tests at the Department of Neurology of Southern Hospital, and the diagnosis of EBV-associated encephalitis should be certified by two or more senior neurologists. 3. Medications Patients should be limited to the following: acyclovir, ganciclovir, glucocorticoids, and antibiotics. 4. EBV encephalitis should be scored according to the criteria for the diagnosis of viral encephalitis, and symptomatic scores such as the modified Rankin Scale (MRS) and Glasglow Score (GCS) should be performed under the supervision of a qualified physician. All the cognitive function scores should follow the International Cognitive Function Scoring Guidelines, and the Trail Making Test (TMT), Brief Assessment of Cognition in Schizophrenia (BACS-SC), Attention and Observation Score (BACS-SC), and Continuous Performance Test-Identical Observation Score (BACS-SC) should be performed respectively. Continuous Performance Test-Identical Pairs (CPT-IP), Working Memory Score (Letter-Number Span (LNS); Wechsler Memory Scale: Spatial Span (WMS-III SS), Verbal Ability Score (Hopkins Verbal Learning Test-Reading (VLT-R), and the Hopkins Verbal Learning Test-Reading (VLTR)). Hopkins Verbal Learning Test-Revised, HVLT-R), the Neuropsychological Assessment Battery (NAB; Brief Visuospatial Memory Test-Revised, BVMT- R), and the Social Cognitive Score (MVMT-R). R), and Social Cognitive Score (Mayer-Salovey-Caruso Emotional Intelligence Test-Managing Emotions branch, MSCEIT-ME). control group 1. Voluntarily sign the informed consent form 2. Age >= 18 3. Gender: Male or female not limited 4. The control group should be healthy and of age and gender, BMI, Individuals with similar smoking and alcohol use as patients should not have underlying diseases or a history of drug use in the past month. 5. The enrolled population should undergo clinical and laboratory examinations at the Neurology Department of Southern Hospital. 6. All control groups must meet the requirement that the individual and their first-degree relatives have no history of neurological disorders. 7. The use of medication for patients should be limited to the following types: acyclovir, ganciclovir, glucocorticoids, and antibiotics.
Exclusion criteria
Exclusion criteria: 1. Subjects should not have a history of HIV and tumors or a history of taking immunosuppression-related medications. 2. Subjects should not have a combined history of other types of infectious diseases and metabolism-related diseases. 3. Subjects should not be dependent on any drugs or drug-related substances (including morphine, cocaine, heroin, amphetamines, etc.), and the use of nicotine products (cigarettes, etc.) and the consumption of alcohol are acceptable. 4. Subjects should also not have any coexisting neurodevelopmental abnormalities related to disorders such as autism spectrum disorders. 5. Subjects should not have any blood-related other infectious diseases such as Hepatitis B. 6. Subjects should not have any ongoing neurologic disease and should have normal neurologic findings and cranial MRI results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tryptophan/ Serotonin;Tryptophan / Canuline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Binding protein markers (such as CXCL13, NfL); | — |
Countries
China
Contacts
Public ContactYuan Chao
Southern Medical University Southern Hospital
Outcome results
None listed