None
Conditions
Interventions
The Oxalidine group:Anesthesia induction and maintenance using Oliceridine
The no opioid group:Anesthesia induction and maintenance using Esketamine
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. ASA I-II; 3. Body mass index 18-30 kg/m^2; 4. Patients scheduled for elective laparoscopic cholecystectomy; 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. ASA >= III; 2. Heart rate less than 50 beats/min; 3. Left ventricular ejection fraction less than 40%; 4. Sick sinus syndrome or second-degree or higher atrioventricular block; 5. Myocardial infarction; 6. Severe hepatic or renal insufficiency; 7. Allergy or contraindication to drugs that may be used in the trial, or preoperative use of drugs known to have antiemetic effects; 8. Chronic pain (pain persisting or recurring for more than 3 months); 9. Preoperative use of sedatives or analgesics; 10. Mental disorder or inability to communicate; 11. Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Nausea and Vomiting;Rate of rescue antiemetic use;Severity of PONV;Pain score;Time to emergence;Extubation time;Relevant times (time to first flatus, first defecation, and discharge);Adverse events; | — |
Countries
China
Contacts
Public ContactJianhui Liu
Shanghai Tongji Hospital
Outcome results
None listed