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Comparison of Metal Clip-Assisted Nylon Loop Pre-ligation, Endoscopic Mucosal Resection with Clip Closure, and Conventional Clip or Nylon Loop Ligation for Resecting Large Pedunculated Polyps (>=1 cm): A Prospective, Multicenter, Randomized Controlled Trial.

Comparison of Metal Clip-Assisted Nylon Loop Pre-ligation, Endoscopic Mucosal Resection with Clip Closure, and Conventional Clip or Nylon Loop Ligation for Resecting Large Pedunculated Polyps (>=1 cm): A Prospective, Multicenter, Randomized Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600121579
Enrollment
Unknown
Registered
2026-04-01
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Polyps

Interventions

Metal Clip-Assisted Nylon Snare Pre-ligation Group:Metal Clip-Assisted Nylon Snare Pre-ligation
EMR + Metal Clip Closure group:EMR + Metal Clip Closure
Simple Metal Clip or Nylon Snare Pre-ligation Technique group:Simple Metal Clip or Nylon Snare Pre-ligation Technique

Sponsors

Nanchong Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with colorectal polyps (either sessile or pedunculated) with a diameter of >= 1 cm; 2. Age: < 80 years old, regardless of gender; 3. Patients hospitalized in 11 participating study hospitals and meeting the eligibility criteria of this study; 4. Voluntarily agree to participate in this study and sign a written informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients taking oral anticoagulants or antiplatelet agents with discontinuation of the drugs for less than 7 days; 2. Patients with other hematological diseases or coagulopathy; 3. Patients with mental disorders who are unable to cooperate with treatment; 4. Patients who refuse to sign the informed consent form.

Design outcomes

Primary

MeasureTime frame
Whether rebleeding has occurred;The time at which rebleeding occurred;Repeat endoscopy for bleeding;Delayed Post-Polypectomy Bleeding;Procedure-Related Perforation Rate;Intraoperative Bleeding;—

Countries

China

Contacts

Public ContactTao Zhang

Nanchong Central Hospital

305514271@qq.com+86 182 2731 2096

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026