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Impact of One-Lung Ventilation on Postoperative Diaphragmatic Function After Video-Assisted Thoracoscopic Lung Resection: A Prospective Observational Study

Impact of One-Lung Ventilation on Postoperative Diaphragmatic Function After Video-Assisted Thoracoscopic Lung Resection: A Prospective Observational Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121576
Enrollment
Unknown
Registered
2026-04-01
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragmatic dysfunction

Interventions

Observational group:None

Sponsors

Jiangsu Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. Aged >=18 years and <80 years; 2. Provided written informed consent prior to study enrollment; 3. Classified as American Society of Anesthesiologists (ASA) Physical Status (PS) Grade II to III; 4. Body mass index (BMI) ranging from 18.5 to 30 kg/m^2; 5. Scheduled to undergo video-assisted thoracoscopic (VATS) lung resection under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Aged >=80 years; 2. Previous history of thoracic surgery; 3. Patients unable to participate in the study due to physical conditions; 4. Presence of severe vital organ failure; 5. Pregnant or lactating female patients; 6. Patients with diaphragmatic excursion (DE) <=1 cm on preoperative diaphragmatic ultrasonography, indicating potential preoperative diaphragmatic dysfunction; 7. History of respiratory tract infection within 4 weeks preoperatively; 8. Patients currently participating in other clinical trials; 9. Patients who refused to participate in this study; 10. Patients with inadequate ultrasonographic visualization of the diaphragm, precluding acquisition of valid diaphragmatic function measurement data.

Design outcomes

Primary

MeasureTime frame
Point-of-Care Ultrasound (POCUS) Measurement Indices of the Diaphragm;

Secondary

MeasureTime frame
EIT measure outcome;Chest Drain Duration;PPCs within 7 days after surgery;Visual Analogue Scale (VAS) score for postoperative pain;length of stay after surgery;ICU Length of Stay;

Countries

China

Contacts

Public ContactHe Jianhua

Jiangsu Cancer Hospital

hejianhua_73@163.com+86 137 7070 1804

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026