Postoperative Cognitive Dysfunction
Conditions
Interventions
Observation group:None
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients in the metabolic syndrome group must meet at least three of the indicators identified in the MetS diagnostic criteria established by the Chinese Diabetes Society (CDS) in 2020: (1) Abdominal obesity (i.e., central obesity): waist circumference >90 cm for men, >85 cm for women; (2) Fasting blood glucose >6.1 mmol/L, and/or 2-hour plasma glucose >7.8 mmol/L, and/or diagnosed diabetes under treatment; (3) Blood pressure >130/85 mmHg, and/or diagnosed hypertension under treatment; (4) Fasting triglycerides >1.7 mmol/L; (5) Fasting HDL-C =40 years; 4. Patients scheduled for gastrointestinal tumor resection under general anesthesia; 5. Participants whose mother tongue is Chinese, with good audiovisual comprehension, able to cooperate to complete neuropsychological tests; 6. Voluntarily participating in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Past neurological history: History of cerebrovascular disease, epilepsy, Parkinson's disease, or other central nervous system degenerative diseases; major cardiovascular or cerebrovascular adverse events occurring recently (within 6 months); 2. Psychiatric and medication history: History of psychiatric disorders, or previous long-term use of psychiatric medications; 3. Preoperative cognitive dysfunction: Cognitive dysfunction assessed preoperatively by the Mini-Mental State Examination (MMSE) (illiterate <=17 points, primary school education <=20 points, secondary school or above education <=24 points); 4. Metabolic interfering factors: Presence of thyroid dysfunction, acute gout attacks, or autoimmune diseases; 5. Poor compliance: Severe communication barriers (such as severe hearing or vision impairment, aphasia, etc.) preventing completion of neurocognitive assessment scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Cognitive Dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;Length of stay in the PACU;Postoperative length of hospital stay;Overall incidence of postoperative complications;Recovery of gastrointestinal function;Unplanned ICU admission rate;Time to emergence; | — |
Countries
China
Contacts
Public ContactYatao Liu
The First Hospital of Lanzhou University
Outcome results
None listed