Major depressive disorder with mixed features
Conditions
Interventions
Subthreshold Group - SIPT:Online group systemic interpersonal therapy (once weekly, 120 minutes per session, 8 sessions total
led by 2 therapists in groups of 6-10 participants)
Subthreshold Group - IPT:Online traditional interpersonal therapy (once weekly, 120 minutes per session, 8 sessions total
Subthreshold Group - TAU:Basic supportive psychotherapy
Suprathreshold Group - SIPT:Online group systemic interpersonal therapy (once weekly, 120 minutes per session, 8 sessions total
Suprathreshold Group - IPT:Online traditional interpersonal therapy (once weekly, 120 minutes per session, 8 sessions total
Suprathreshold Group - TAU:Routine pharmacological treatment (restricted medications: fluoxetine, escitalopram, paroxetine, sertraline, venlafaxine
haloperidol, risperidone, paliperidone, olanzapine, aripiprazole, lurasidone, quetiapine
lithium carbonate, valproate, lamotrigine)
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Suprathreshold Group: The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version will be carried out by two physicians with consistent training. The adolescents who are aged 12-18 and are diagnosed with major depressive disorder could be enrolled; 2.Suprathreshold Group: meeting DSM-5 criteria for Mixed Features; 3.Suprathreshold Group: The patient is currently in a state of mild to moderate depression without meeting the criteria for moderate mania or above (HAMD =7 and <24, YMRS <15); 4.Suprathreshold Group: Adolescents and their parents could give full informed consent and provide written informed consent documents. 5.Suprathreshold Group: The participants can cooperate with the scale examination and can participate in online training. 6.Suprathreshold Group: The dose of psychiatric medication was stable for more than 6 weeks; 7.Subthreshold Group: Adolescents aged 12-18 with PHQ-9 =10 and MDQ =6, who, as assessed by the K-SADS-PL interview, did not meet the diagnostic criteria for either major depressive disorder or bipolar disorder both historically and currently. 8.Subthreshold Group: Adolescents and their parents could give full informed consent and provide written informed consent documents. 9.Subthreshold Group: The participants can cooperate with the scale examination and can participate in training. 10.Subthreshold group: No psychotropic medications administered.
Exclusion criteria
Exclusion criteria: 1.Suprathreshold group: Meeting DSM-5 diagnostic criteria for bipolar disorder or schizophrenia. 2.Suprathreshold group: Presence of significant suicidal ideation or behavior, and/or evident non-suicidal self-injury (NSSI), requiring additional treatment, crisis intervention, or more intensive psychological support. 3.Suprathreshold group: Subjects with a Wechsler IQ score <80, or illiteracy, or inability to cooperate with completing scale assessments and training. 4.Suprathreshold group: Currently receiving other forms of psychotherapy. 5.Subthreshold group: Meeting DSM-5 diagnostic criteria for schizophrenia. 6.Subthreshold group: Subjects with a Wechsler IQ score <80, or illiteracy, or inability to cooperate with completing scale assessments and training. 7.Subthreshold group: Currently receiving other forms of psychotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emotional Symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interpersonal Neural Synchrony;Disease Progression During Follow-up Period;Health Economics;Social Functioning;Acceptability; | — |
Countries
China
Contacts
Public ContactSun Hongqiang
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed