Non-suicidal self-injury
Conditions
Interventions
True stimulation group:Temporal interference stimulation
Healthy control group:NA
Sponsors
Zhongda Hospital Southeast university
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1) NSSI group: Participants in the NSSI group were required to meet the following criteria: (1) Fulfillment of the diagnostic criteria for non-suicidal self-injury (NSSI) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, defined as the presence of non-lethal self-injurious behaviors without explicit suicidal ideation or intent. Typical behaviors included deliberate cutting or stabbing of the skin with sharp objects, burning the skin, or producing multiple wounds on the same body area, particularly at sites that are easily concealed but accessible (e.g., forearms or the anterior thighs). (2) Age between 12 and 18 years. (3) Both the participant and their legal guardian fully understood the study procedures and voluntarily agreed to participate. (4) No use of antipsychotic or antidepressant medications within the past month. (5) No electroconvulsive therapy or other physical treatments, including transcranial magnetic stimulation, within the past six months. (6) Ability to undergo MRI examination. Based on the scores of the UPPS-P Impulsive Behavior Scale, participants were further categorized into high-impulsivity and low-impulsivity subgroups using the mean total score as the cutoff (above and below the mean, respectively). 2) Healthy control group: A demographically matched healthy control group was recruited during the same period. Inclusion criteria were as follows: (1) No subjective complaints of cognitive impairment. (2) Normal neurological examination findings. (3) Normal performance on core cognitive assessments, with depression and anxiety scores within the normal range. (4) Scores on multidimensional neuropsychological assessment scales within the normative range for age and educational level. Similarly, based on UPPS-P total scores (using the mean score as the cutoff), participants were classified into high-impulsivity and low-impulsivity subgroups (above and below the mean, respectively).
Exclusion criteria
Exclusion criteria: Participants were excluded from the study if any of the following conditions were present: 1. History of impaired consciousness. 2. Family history of hereditary diseases. 3. Presence of major neurological or systemic disorders, including central nervous system infections, traumatic brain injury, epilepsy, multiple sclerosis, toxic or metabolic diseases, intracranial tumors, hypothyroidism, diabetes mellitus, or other significant medical conditions. 4. History of major psychiatric disorders, such as schizophrenia, manic episodes, bipolar disorder, or personality changes. 5. Individuals at high risk of suicide, including those with recent or persistent suicidal ideation, suicide plans, previous suicide attempts, or severe mental disorders and psychosocial risk factors related to suicide. 6. Comorbid severe diseases affecting the cardiovascular, hepatic, renal, cerebral, or hematopoietic systems. 7. Contraindications for MRI scanning, including implanted electronic devices or metallic implants. 8. History of electroconvulsive therapy. 9. Evidence of white matter lesions on T2-weighted MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-harm Frequency and Severity Score;Degree of depression;Cognition;Sleep quality; | — |
Countries
China
Contacts
Public ContactHe Cancan
Southeast University; Zhongda Hospital Southeast university
Outcome results
None listed