Dry eye disease
Conditions
Interventions
Dry eye with pain group:None
Normal group:None
Corneal neuropathic pain group:None
Dry eye without pain group:None
Sponsors
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–70 years, with no restriction on sex; able to understand and complete questionnaires and undergo relevant examinations; 2. Normal control group: OSDI score = 13 and NIBUT 9 points, corneal staining > 5 points, lid margin staining width >= 2 mm and/or height >= 25%, with an NRS score of 0; 4. Dry eye with pain group: OSDI score >=13 and NIBUT 9 points, corneal staining > 5 points, lid margin staining width >= 2 mm and/or height >=25%, with an NRS score >= 1 and pain duration of at least 3 months; 5. Corneal neuropathic pain group: OSDI score = 1 and pain duration of at least 3 months;
Exclusion criteria
Exclusion criteria: 1.Inability or refusal to provide written informed consent; 2.History of ocular surgery or ocular trauma; 3.Contact lens use within the past 1 month; 4.Immune-related dry eye, allergic conjunctivitis, or pterygium; 5.Ocular surface or corneal infection within the past 3 months; 6.Uveitis or glaucoma; 7.Known allergy to topical ocular agents such as sodium fluorescein, proparacaine, or tobramycin eye drops; 8.Presence of severe systemic diseases; 9. Presence of systemic diseases that significantly affect pain perception (e.g., diabetic neuropathy, multiple sclerosis, postherpetic neuralgia); 10.Use of systemic medications that may affect pain sensitivity within the past 1 month (e.g., opioids, nonsteroidal anti-inflammatory drugs, antidepressants, anticonvulsants);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal sensation and corneal mechanical pain threshold;Obital Mechanical Pain Pressure Threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale;Ocular Pain Assessment Survey;Schirmer’s Test I;Neuropathic Pain Symptom Inventory–Eye;Corneal fluorescein staining;confocal microscope;Non-Invasive Break-Up Time;Ocular Surface Disease Index; | — |
Countries
China
Contacts
Public ContactZiyan Chen
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Outcome results
None listed