Acute cerebral hemorrhage on a plateau
Conditions
Interventions
Intensive antihypertensive group:In the intensive antihypertensive group, the target is to reduce and maintain systolic blood pressure at 120–139 mmHg within 2 hours after randomizati
Standard antihypertensive group:In the standard antihypertensive group, the target is to reduce and maintain systolic blood pressure at 140–179 mmHg within 2 hours after randomizatio
Sponsors
The Army Specialized Medical Center of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Acute spontaneous intracerebral hemorrhage (confirmed by CT), with symptoms appearing within 6 hours of seeking medical attention; 3. The patient's systolic blood pressure (SBP) is between 150 and 220 mmHg; 4. The onset occurred in an altitude environment (altitude >= 1500 meters); 5. The doctor believes that the patient is likely to start receiving intensive blood pressure reduction treatment within 2 hours after randomization; 6. The informed consent form has been obtained and signed.
Exclusion criteria
Exclusion criteria: 1. Secondary cerebral hemorrhage that has been clearly identified, including: rupture of cerebral aneurysms, arteriovenous malformations, brain tumors, trauma, and coagulation dysfunction; 2. The patient has a clear plan for immediate surgery to remove the hematoma; 3. Severe complications (such as end-stage renal failure, heart failure, active bleeding disorders, hypoxic respiratory failure); 4. Expected survival time 2); 6. Unable to monitor SpO2 or unable to obtain basic life support; 7. Presence of indications for blood pressure reduction, such as clear contraindications to commonly used antihypertensive drugs or hypersensitivity to antihypertensive drugs; 8. Pregnancy; 9. Participating in other clinical studies; 10. Existing conditions that may affect the subject's compliance, or the researchers consider other reasons as not suitable for the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse event (AE);Glasgow Coma Scale (GCS);National Institutes of Health Stroke Scale (NIHSS);Laboratory examinations include, but are not limited to, blood routine, liver and kidney function, electrolytes, and coagulation profile.;Modified Rankin Scale (mRS);Medical history taking;EuroQOL score: EQ-5D, European Quality of Life-5 Dimensions questionnaire score;Unenhanced CT scan of the head;Office blood pressure;Patient treatment course: including medications, operation records, etc.;Vital signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrocardiogram; | — |
Countries
China
Contacts
Public ContactZeng Chunyu
The Army Specialized Medical Center of the People's Liberation Army of China
Outcome results
None listed