cardiac disease
Conditions
Interventions
P:propofol effect chamber target-controlled concentration 2.0 mg/kg
A:ciprofol effect chamber target-controlled concentration 1.2 mg/kg
B:ciprofol effect chamber target-controlled concentration 1.3 mg/kg
C:ciprofol effect chamber target-controlled concentration 1.4 mg/kg
Sponsors
The Eighth Affiliated Hospital, SunYat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18–75 years ; 2. Body mass index (BMI): 18–30 kg/m² ; 3. American Society of Anesthesiologists (ASA) classification: III–IV ; 4. New York Heart Association (NYHA) cardiac function classification: II–III ; 5. Planned procedures: Coronary artery bypass grafting (CABG) and/or cardiac valve replacement under extracorporeal circulation.
Exclusion criteria
Exclusion criteria: 1.History of psychiatric or neurological disorders (e.g., cerebrovascular disease, epilepsy, Alzheimer's disease, schizophrenia, depression) ; 2.Acute heart failure or angina pectoris before anesthesia induction; 3.Severe pulmonary, hepatic, or renal dysfunction ; 4.Allergy to relevant medications; 5.Alcoholism or drug abuse ; 6.Q-T interval =450 ms. Q-T interval =450 ms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;CO;Stroke volume;Systemic vascular resistance;Stroke volume variability;Incidence of hypotension during the induction phase;Incidence of bradycardia during the induction phase;the dosage of vasoactive drugs administered during the induction phase; | — |
Countries
China
Contacts
Public ContactPeng Yue
The Eighth Affiliated Hospital, SunYat-Sen University
Outcome results
None listed