Colonic spasm and colorectal polyps
Conditions
Interventions
Experimental group:Endoscopic irrigation with 0.1% menthol solution combined with dimethyl silicone oil suspension
Control group:Endoscopic irrigation with a water suspension prepared from dimethyl silicone oil and normal saline
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Ages 18–75 years, both sexes/gender not limited. 2. Planned for colonoscopy (for screening, diagnostic, or follow-up purposes); 3. Adequate bowel preparation quality (Boston Bowel Preparation Scale score >= 6); 4. Voluntarily signed informed consent and is able to cooperate in completing study-related assessments.
Exclusion criteria
Exclusion criteria: 1. Allergic to menthol, cyclodextrin, or related substances; 2. History of severe intestinal diseases (such as ulcerative colitis, Crohn’s disease, intestinal perforation, intestinal obstruction, intestinal tumors, etc.); 3. With combined severe dysfunction of major organs such as the heart, liver, kidneys, or lungs, or coagulation disorders. 4. Pregnant or lactating women; 5. Those who have used anticholinergic drugs, calcium channel blockers, or other antispasmodic medications within one week prior to the examination. 6. Individuals with mental illness or cognitive impairment that prevents them from cooperating with the study. 7. Those with a history of contraindications to colonoscopy or serious adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intestinal spasm;Adenoma detection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Spasm inhibition rate;Polyp detection rate;Time of cecal intubation;Withdrawal time;Usage rate of intravenous antispasmodics; | — |
Countries
China
Contacts
Public ContactJianning Yao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed