Postoperative Nausea and Vomiting
Conditions
Interventions
Fospropofol Disodium Group?F Group:Fospropofol Disodium
Propofol Group?P Group:Propofol
Sponsors
West China Tianfu Hospital,Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–80 years, any sex; 2.ASA physical status ?–?; 3.Undergoing elective non-cardiac surgery under general anesthesia; 4.Induction regimen using propofol or fospropofol disodium as the primary sedative;
Exclusion criteria
Exclusion criteria: 1.Preoperative nausea/vomiting or use of antiemetics within 24 hours; 2.History of chronic nausea/vomiting (e.g., gastroparesis, post-chemotherapy); 3.Allergy to propofol, fospropofol disodium, or excipients (e.g., lipid emulsion, soybean oil); 4.Severe hepatic/renal dysfunction (Child-Pugh C or preoperative Cr > 2 mg/dL), cardiac insufficiency (NYHA ?–?); 5.Long-term opioid or sedative-hypnotic abuse; 6.Pre-existing CNS disorders (e.g., schizophrenia, epilepsy); 7.Required secondary surgery or ICU admission during/after surgery; 8.Incomplete medical records preventing PONV assessment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV in PACU; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue antiemetic rate;Hypotension;Arrhythmia;Severity of PONV;Extubation time;Hypoxemia; | — |
Countries
China
Contacts
Public ContactGuangchao Zhang
West China Tianfu Hospital,Sichuan University
Outcome results
None listed