Chronic Renal Failure
Conditions
Interventions
Experimental Group:1.Slow Flushing Heparinization:
Connect the perfusion device to the dialyzer, and attach the arterial end tubing to this pre-flushing system. Start the blood pump and perform the in
Control Group:1.Use normal saline to expel air from the arterial end of the dialysis tubing, then connect the arterial end to the hemoperfusion device, and subsequently connect the hemoperfusion devic
Sponsors
Pangang Group General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 80 years, regardless of gender; 2.Diagnosed with end-stage renal disease due to chronic nephritis, diabetic nephropathy, or hypertensive nephropathy, with stable condition, receiving regular hemodialysis (2–3 times per week), and requiring regular HD+HP treatment (HP frequency =2 times per month); 3.Conscious, with good communication skills, able to understand and cooperate with the relevant procedures, examinations, and follow-ups of this study; 4.Voluntarily participating in this study and providing written informed consent signed by the participant or their legal guardian.
Exclusion criteria
Exclusion criteria: 1. Presence of severe cognitive impairment or a history of mental illness (such as schizophrenia or major depressive disorder) that would prevent cooperation with the study; 2. Comorbidities such as active bleeding, severe coagulation dysfunction, or a previous history of allergy to anticoagulants such as heparin; 3. Comorbidities such as malignant tumors, severe heart failure (NYHA Class IV), or severe arrhythmia, with an estimated survival period of less than 6 months or inability to tolerate HD+HP treatment; 4.Participation in other interventional clinical studies during the research period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coagulation Grading; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment Efficiency ;Incidence of acute complications during treatment; | — |
Countries
China
Contacts
Public ContactYuan Hongmei
Pangang Group General Hospital
Outcome results
None listed