Vertebral Compression Fracture
Conditions
Interventions
Remimazolam (R) group:The initial dose was 2.5–5 mg. Surgery was initiated once adequate sedation was achieved (MOAA/S score <= 4). If adequate sedation was not attained after the initial dose, 1.25–2
when the MOAA/S score was <= 4, the infusion rate was adjusted to maintain continuous sedation at 0.3~0.5 mg·kg-1·h-1 . The intraoperative sedation depth was maintained at a MOAA/S score of 2–4.
Dexmedetomidine group (Group M):The initial dose was 0.3 µg/kg administered over 10 minutes. The patient’s sedation level was monitored intraoperatively
when the MOAA/S score was <= 4, the infusion rate was adjusted to maintain continuous sedation at 0.20~0.75µg·kg-1·h-1. The intraoperative sedation depth was maintained at a MOAA/S score of 2–4.
Sponsors
Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged >=65 years with a body mass index (BMI) of 18–28 kg/m^2, diagnosed as frail according to the Fried Frailty Scale, scheduled for percutaneous vertebroplasty with an operation duration not exceeding 120 minutes; those who clearly understand and voluntarily participate in this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: Patients with hypersensitivity to benzodiazepines, opioids, or lidocaine; a history of using benzodiazepines or opioids within the past 3 months, epilepsy, any psychiatric disorder, or addiction to analgesics or hypnotics; patients scheduled for tracheal intubation; those judged to have difficult airway management; visual, auditory, or verbal communication disorders; obesity; bradycardia (heart rate (HR) < 60 beats per minute); heart block; and patients who refused to provide informed consent were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypotension;Hypertension;Bradycardia;Tachycardia;Decreased respiratory rate;Hypoxia;Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation duration, recovery duration;Patient and surgeon satisfaction with anesthesia management;The patient's overall pain experience; | — |
Countries
China
Contacts
Public ContactMeijuan Sun
Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an)
Outcome results
None listed