Sepsis
Conditions
Interventions
Sepsis Cohort:None (observational prospective cohort study, only recording natural course and standard treatment)
Sponsors
The Sixth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old; 2.Definite diagnosis of sepsis, meeting the Sepsis-3.0 criteria: presence of confirmed infection (infection site such as lung, abdominal cavity, urinary system, etc. must be verified by clinical, laboratory or imaging evidence), and Sequential Organ Failure Assessment (SOFA) score >= 2 points; 3.Time interval from sepsis onset to ICU admission = 3 months, and the current sepsis episode is not directly related to previous episodes. 5.No anticoagulant/antiplatelet/thrombolytic therapy received within 72 hours before the confirmed diagnosis of sepsis; 6.Baseline data collection can be completed within 24 hours after ICU admission; 7.Expected survival time >= 72 hours; 8.Written informed consent signed by the patient or his/her legal representative.
Exclusion criteria
Exclusion criteria: 1.Patients with non-first diagnosis of sepsis who do not meet the 4th inclusion criterion; 2.The current sepsis episode is a recurrence (defined as being caused by the same infection source/pathogen as the previous sepsis episode, or the time interval from clinical cure of previous sepsis is 24 hours, or the onset time cannot be clearly traced; 5.Complicated with congenital coagulation disorders (e.g., hemophilia) or severe chronic liver failure (Child-Pugh grade C or above); complicated with end-stage diseases: e.g., advanced malignant tumor (expected survival time < 6 months), end-stage renal disease requiring long-term dialysis with expected survival time < 6 months; 6.Complicated with oral diseases or limited by conditions that prevent sublingual microcirculation detection (e.g., severe oral infection, massive oral hemorrhage, post-oral surgery); 7.Pregnant or lactating women; 8.Refuse or are unable to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality at 28 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microcirculatory functional recovery rate within 72 hours after admission;Dynamic expression profile of coagulation-fibrinolysis biomarkers;Change in microcirculatory parameters within 72 hours after admission;Correlation between coagulation biomarkers and microcirculatory parameters;Duration of ICU stay;Incidence of multiple organ failure (MOF);Performance of integrated coagulation-fibrinolysis biomarker prediction model; | — |
Countries
China
Contacts
Public ContactYang Chunhua
The Sixth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed